I. GENERAL PHARMACOLOGY
1. Object and branches of pharmacology. Connection with other sciences. Historical review. Sourses of drugs.
2. Drug - definition, origin, nomenclature. Drug form and drug product - definition. Drug preparations.
3. Drug development - stages and phases.
4. Transmembrane transport of drugs.
5. Drug absorption after various routes of administration.
6. Drug distribution.
7. Drug metabolism.
8. Drug excretion.
9. Specific and non-specific type of drug action. Types of receptors.
10. Characteristics of the receptor action of the drugs.
11. Drug properties and environmental factors affecting drug pharmacokinetics and drug pharmacodynamics.
12. Factors from the human body affecting the drug pharmacokinetics and drug pharmacodynamics.
13. Effects occurring after repeated drug administration.
14. Drug intex*actions at a pharmacokinetic level.
15. Drug interactions at a pharmacodynamic level.
16. Pharmaceutical drug interactions (drug incompatibility). Drugs affecting clinical laboratory tests. Interactions of drugs with foods.
IL PHARMACOLOGY OF ORGAN SYSTEMS
17. Pharmacological modulation of the cholinergic neurotransmission - levels and mechanisms.
18. Cholinergic drugs (cholinomimetics).
19. Antimuscarinic drugs (M-cholinolytics).
20. Neuromuscular blockers (Peripheral muscle relaxants).
21. Pharmacological modulation of the adrenergic neurotransmission ~ levels and mechanisms.
22. Adrenomimetics.
23. Alpha-adrenergic blocking agents. Agonists of the central presynaptic a2a-adrenergic receptors.
24. Beta-adrenergic blocking agents.
25. Histamine antagonists.
26. Serotonin agonists and antiserotoninergic drugs.
27. Local anaesthetics.
28. General anaesthetics.
29. Hypnotics. Sedative drugs with plant origin.
30. Antiepileptic drugs,
31. Antiparkinsonian drugs.
32. Neuroleptics.
33. Anxiolytics. Muscle relaxants with central action.
34. Antidepressants. Antimanic drugs.
35. Psychostimulants. Nootropic drugs.
36. Opioid analgesics.
37. Nonsteroidal anti-inflammatory drugs. Non-opioid analgesics.
38. Calcium channel blockers.
39. Drugs that affect the renin-angiotensin-aldosterone system.
40. Antihypertensive drugs.
41. Antiarrhythmic drugs.
42. Antianginal (antistenocardia!) drugs,
43. Drugs for the treatment of heart failure.
44. Diuretics.
45. Peripheral vasodilators. Capillarotonic and venotonic drugs.
46. Antimigraine drugs.
47. Antidyslipidemic drugs.
48. Haematopoietic drugs.
49. Haemostatics (antiheamorrhagxc) drugs.
50. Anticoagulants,
51. Fibrinolytics. Antiplatelet drugs.
52. Antiasthmatic drugs.
53. Antitussive drugs.
54. Antiulcer drugs.
55. Antiemetic drugs.
56. Hepatoprotectors. Drugs that affect bile secretion. Pancreatic enzyme preparations.
57. Laxative drugs.
58. Antidiarrheal drugs.
59. Vitamins - clinical applications.
60. Drugs that affect calcium and phosphorus exchange. Antigout drugs.
61. Hypothalamic and pituitary hormones - drugs and clinical application.
62. Thyreoactive drugs,
63. Insulins and insulin analogues.
64. Oral antidiabetic drugs.
65. Glucocorticoids and mineralcorticoids.
66. Female sex hormones - drugs and clinical application. Honnonal contraceptives.
67. Male sex hormones - drugs and clinical application. Anabolic drugs. Drugs for the treatment of erectile dysfunction.
68. Uteroactive drugs.
69. Antibiotics - classification; mechanisms, type of action.and antimicrobial spectrum. Principles of the rational antibiotic therapy and prophylaxis.
70. Penicillins.
71. Cephalosporins.
72. Carbapenems and monobactams. Glycopeptides.
73. Aminoglycosides.
74. Tetracyclines.
75. Macrolides and ketolides.
76. Lincosamides. Amphenicols.
77. Sulfanoamides,
78. Quinolones.
79. Antituberculosis drugs. Antileprosy drugs.
80. Antimycotics.
81. Antiviral drugs.
82. Antiprotozoal drugs.
83. Antihelmintic drugs.
84. Antiseptics and disinfectants.
85. Antitumor chemotherapeuticals.
86. Hormonal antitumor drugs. Target antitumor drugs.
87. Immunomodulators.
III. DRUG TOXICOLOGY
88. Side effects of drugs.
89. Organ toxic effects of drugs.
90. Fetal damage caused by drugs.
91. Principles of reatment of acute drug poisoning.
92. Antidotes.
93. Acute intoxication and abuse of opioids. Principles of the treatment.
94. Acute intoxication and abuse of benzodiazepines. Principles of the treatment.
