From antibiogram to prescription

' A. ANTIBIOTICS;

CLASSIFICATION, SPECTRA AND MECHANISMS Or ACTION

Introduction p.S

L Classification of antibiotics   p.9

IL Antibiotics active on the bacterial cell wail p.S;

ILL Bacterial cell wall structure   pL

11.2. Mechanism of action of (5-lactams P.14

11.3. Mechanism of action of glycopeptides PЛ9

11.4. Mechanism of action of fosfomycin p.lf

III. Antibiotics active on protein or nucleic add synthesis . p.if

III.L Mechanism of action of aminoglycosides p.19

111.2. Mechanism of action of quinolones p.20

111.3. Mechanisms of action of the macrolide, lincosamide..

streptogramiri and ketolide (MLSK) group p.2l

111.4. Mechanisms of action of other antibiotics p.22

IV. Anti-mycobacterial antibiotics p.23

IV. 1. Molecules active against M, tuberculosis p.23

IV.2. Molecules active against atypical mycobacteria p.24

IV.3. Mechanisms of action of anti-tuberculous drugs . .p.24

IV.4. Resistance mechanisms in mycobacteria .p.25

IV.5, Epidemiology of resistance in tuberculosis p.26

Be BACTERIAL RESISTANCE TO ANTIBIOTICS

L General c.L

IL Acquired resistance mechanisms

III. Resistance mechanisms by antibiotic family .p.SC

111.1. Resistance to [3-lactams p.3G

111.2. Aminoglycoside resistance .. P.32

111.3. Quinolone resistance c.34

111.4. Glycopeptide resistance   р.ЗЬ

111.5. Macrolide, lincosamide, streptogramin and ketolide resistance p.36

111.6. Resistance to other antibiotics ... p.37

L ANTIBIOTIC PHARMACODYNAMICS:

BASIC AND PRACTICAL ASPECTS

Introduction .

L The main pharmacodynamic parameters p.SS

1.1. Time over MIC P-3?

1.2. Area under the time/concentration curves relative to MIC (AUC/MIC) p.40

1.3. The inhibitory quotient (IQ) p-4T